Hepatic regeneration from hematopoietic stem cells

被引：43

作者：

Austin, TW ^{[1
]}

Lagasse, E ^{[1
]}

机构：

[1] StemCells Inc, Palo Alto, CA 94304 USA

来源：

MECHANISMS OF DEVELOPMENT | 2003年 / 120卷 / 01期

关键词：

hematopoietic stem cell; cell lineage; regeneration; hepatocyte; transplantation; transdetermination; fusion;

D O I：

10.1016/S0925-4773(02)00339-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In recent years, numerous investigators have reported novel cellular fates of multipotent stem or progenitor cells. In this review, we discuss the unexpected observations that hematopoietic stem cells can contribute to the hepatocyte lineage in humans and in rodent models of liver disease and regeneration. A key unresolved issue regarding hepatic regeneration from hematopoietic stem cells is whether the mechanism occurs through transdetermination, cell fusion, or other processes. A better understanding of the various stem or progenitor cells of the hepatic lineage may facilitate cellular transplantation approaches for the correction of hepatic function in patients with end-stage liver disease. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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收藏

页码：131 / 135

页数：5

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