In Vitro and In Vivo Activities of 1-Hydroxy-2-Alkyl-4(1H)Quinolone Derivatives against Toxoplasma gondii

被引：17

作者：

Bajohr, Lara Liv ^{[2
]}

Ma, Ling ^{[3
]}

Platte, Christian ^{[1
]}

Liesenfeld, Oliver ^{[2
]}

Tietze, Lutz F. ^{[3
]}

Gross, Uwe ^{[1
]}

Bohne, Wolfgang ^{[1
]}

机构：

[1] Univ Med Gottingen, Inst Med Mikrobiol, D-37075 Gottingen, Germany

[2] Charite, Inst Mikrobiol & Hyg, D-12203 Berlin, Germany

[3] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 01期

关键词：

HIGH-AFFINITY INHIBITOR; II NADH DEHYDROGENASE; PLASMODIUM-FALCIPARUM; REACTIVATED TOXOPLASMOSIS; MURINE MODEL; ATOVAQUONE; RESISTANCE; 1-HYDROXY-2-DODECYL-4(1H)QUINOLONE; PARASITES; MALARIA;

D O I：

10.1128/AAC.01001-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

1-Hydroxy-2-dodecyl-4(1H) quinolone (HDQ) was recently identified as a Toxoplasma gondii inhibitor. We describe here two novel 1-hydroxyquinolones, which displayed 50% inhibitory concentrations 10- and 5-fold lower than that of HDQ. In a mouse model of acute toxoplasmosis, these two compounds and HDQ reduced the percentages of infected peritoneal cells and decreased the parasite loads in lungs and livers. Compound B showed a tendency toward lowering parasite loads in brains in a mouse model of toxoplasmic encephalitis.

引用

页码：517 / 521

页数：5

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