Pervasive adaptive evolution in mammalian fertilization proteins

被引:400
作者
Swanson, WJ [1 ]
Nielsen, R
Yang, QF
机构
[1] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
[2] Univ Calif Riverside, Dept Biol, Riverside, CA 92521 USA
[3] Univ Calif Riverside, Dept Genet, Riverside, CA 92521 USA
[4] Cornell Univ, Dept Biol Stat & Computat Biol, Ithaca, NY 14853 USA
关键词
positive Darwinian selection; sexual conflict; fertilization; likelihood ratio test; speciation;
D O I
10.1093/oxfordjournals.molbev.a004233
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mammalian fertilization exhibits species specificity, and the proteins mediating sperm-egg interactions evolve rapidly between species. In this study, we demonstrate that the evolution of seven genes involved in mammalian fertilization is promoted by positive Darwinian selection by using likelihood ratio tests (LRTs). Several of these proteins are sperm proteins that have been implicated in binding the mammalian egg coat zona pellucida glycoproteins, which were shown previously to be subjected to positive selection. Taken together, these represent the major candidates involved in mammalian fertilization, indicating positive selection is pervasive amongst mammalian reproductive proteins. A new LRT is implemented to determine if the d(N)/d(S) ratio is significantly greater than one. This is a more refined test of positive selection than the previous LRTs which only identified if there was a class of sites with a d(N)/d(S) ratio >1 but did not test if that ratio was significantly greater than one.
引用
收藏
页码:18 / 20
页数:3
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