Wnts and TGFβ in synaptogenesis:: Old friends signalling at new places

被引:87
作者
Packard, M [1 ]
Mathew, D [1 ]
Budnik, V [1 ]
机构
[1] Univ Massachusetts, Dept Biol & Mol & Cellular, Biol Grad Program, Amherst, MA 01003 USA
关键词
D O I
10.1038/nrn1036
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The formation of mature synaptic connections involves the targeted transport and aggregation of synaptic vesicles, the gathering of presynaptic release sites and the clustering of postsynaptic neurotransmitter receptors and ion channels. Positional cues are required to orient the cytoskeleton in the direction of neuronal outgrowth, and also to direct the juxtaposition of synaptic protein complexes at the pre- and postsynaptic membranes. Both anterograde and retrograde factors are thought to contribute positional information during synaptic differentiation, and recent studies in vertebrates and invertebrates have begun to uncover a new role in this process for proteins that are essential for pattern formation in the early embryo.
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收藏
页码:113 / 120
页数:8
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