Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species

被引：38

作者：

Magda, D

Gerasimchuk, N

Lecane, P

Miller, RA

Biaglow, JE

Sessler, JL

机构：

[1] Pharmacycl Inc, Sunnyvale, CA 94085 USA

[2] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA

[3] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 22期

关键词：

D O I：

10.1039/b208760j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Motexafin gadolinium (MGd) oxidizes ascorbate, in neutral buffer and in cell culture, forming reactive oxygen species and a coordination polymer with oxalate.

引用

页码：2730 / 2731

页数：2

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