Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species

被引：38

作者：

Magda, D

Gerasimchuk, N

Lecane, P

Miller, RA

Biaglow, JE

Sessler, JL

机构：

[1] Pharmacycl Inc, Sunnyvale, CA 94085 USA

[2] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA

[3] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 22期

关键词：

D O I：

10.1039/b208760j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Motexafin gadolinium (MGd) oxidizes ascorbate, in neutral buffer and in cell culture, forming reactive oxygen species and a coordination polymer with oxalate.

引用

页码：2730 / 2731

页数：2

共 20 条

[11]

Miller RA, 2001, CLIN CANCER RES, V7, P3215

[12] In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer [J].

Miller, RA ;

Woodburn, K ;

Fan, Q ;

Renschler, MF ;

Sessler, JL ;

Koutcher, JA .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1999, 45 (04) :981-989

[13] A MICROPLATE ASSAY FOR THE DETECTION OF OXIDATIVE PRODUCTS USING 2',7'-DICHLOROFLUORESCIN-DIACETATE [J].

ROSENKRANZ, AR ;

SCHMALDIENST, S ;

STUHLMEIER, KM ;

CHEN, WJ ;

KNAPP, W ;

ZLABINGER, GJ .

JOURNAL OF IMMUNOLOGICAL METHODS, 1992, 156 (01) :39-45

[14]

Rosenthal DI, 1999, CLIN CANCER RES, V5, P739

[15] Pulse radiolytic studies of metallotexaphyrins in the presence of oxygen:: Relevance of the equilibrium with superoxide anion to the mechanism of action of the radiation sensitizer motexafin gadolinium (Gd-Tex2+, Xcytrin) [J].

Sessler, JL ;

Tvermoes, NA ;

Guldi, DM ;

Hug, GL ;

Mody, TD ;

Magda, D .

JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (07) :1452-1457

[16] One-electron reduction and oxidation studies of the radiation sensitizer gadolinium(III) texaphyrin (PCI-0120) and other water soluble metallotexaphyrins [J].

Sessler, JL ;

Tvermoes, NA ;

Guldi, DM ;

Mody, TD ;

Allen, WE .

JOURNAL OF PHYSICAL CHEMISTRY A, 1999, 103 (07) :787-794

[17]

STRATFORD IJ, 1978, BRIT J CANCER, V37, P129

[18] Effects of motexafin gadolinium on tumor metabolism and radiation sensitivity [J].

Xu, S ;

Zakian, K ;

Thaler, H ;

Matei, C ;

Alfleri, A ;

Chen, YC ;

Koutcher, JA .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 49 (05) :1381-1390

[19]

Young SW, 1999, P NATL ACAD SCI USA, V96, P2569

[20] Gadolinium(III) texaphyrin: A tumor selective radiation sensitizer that is detectable by MRI [J].

Young, SW ;

Qing, F ;

Harriman, A ;

Sessler, JL ;

Dow, WC ;

Mody, TD ;

Hemmi, GW ;

Hao, YP ;

Miller, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) :6610-6615

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