Use of the Semiconductor Nanotechnologies "Quantum Dots" for in vivo Cancer Imaging

被引：9

作者：

Ciarlo, Monica ^{[1
]}

Russo, Patrizia ^{[1
]}

Cesario, Alfredo ^{[2
,3
]}

Ramella, Sara ^{[4
]}

Baio, Gabriella ^{[5
]}

Neumaier, Carlo E. ^{[5
]}

Paleari, Laura ^{[1
]}

机构：

[1] Natl Inst Canc Res, Lung Canc Unit, I-16132 Genoa, Italy

[2] Catholic Univ, Thorac Surg Unit, Rome, Italy

[3] IRCCS San Raffaele, Rome, Italy

[4] Univ Campus Biomed, Dept Radiotherapy, Rome, Italy

[5] Natl Inst Canc Res, Radiodiagnost Unit, I-16132 Genoa, Italy

来源：

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY | 2009年 / 4卷 / 03期

关键词：

Quantum dots; in vivo imaging; cancer; MESENCHYMAL STEM-CELLS; DRUG DEVELOPMENT; MODELS; NANOCRYSTALS; INHIBITION; ANIMALS; AGENTS; MOUSE; MICE;

D O I：

10.2174/157489209789206841

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Non-invasive in vivo imaging offers great potential to facilitate translational drug development research at the animal testing phase. The emerging luminescent nanoparticles or quantum dots provide a new type of biological agents that can improve these applications. The advantages of luminescent nanoparticles for biological applications include their high quantum yield, color availability, good photo-stability, large surface-to-volume ratio, surface functionality, and small size. These properties could improve the sensitivity of biological detection and imaging by at least 10- to 100-fold and make them an exceptional tool for live-cell imaging. In this review patents on applications of semiconductor quantum dots for in vivo imaging are discussed.

引用

页码：207 / 215

页数：9

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