Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets

被引:396
作者
Hommes, DW
Peppelenbosch, MP
van Deventer, SJH
机构
[1] Acad Med Ctr, Dept Gastroenterol & Hepatol, NL-1105 AZ Amsterdam, Netherlands
[2] Acad Med Ctr, Dept Expt Internal Med, NL-1105 AZ Amsterdam, Netherlands
关键词
D O I
10.1136/gut.52.1.144
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Over the last decade important advances have been made in our understanding of the molecular events underlying cellular responses to extracellular signals. Increased understanding of signal transduction mechanisms and gene regulation involved in immune responses has created opportunities for the discovery of novel therapeutic compounds useful in treating inflammatory disorders. One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses. Here, our current understanding of the MAP kinase pathway is reviewed, as well as recent advances in the design of novel agents that are able to modulate the activity of these signalling cascades.
引用
收藏
页码:144 / 151
页数:8
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