Prognostic value of baseline human immunodeficiency virus type 1 DNA measurement for disease progression in patients receiving nucleoside therapy

被引：46

作者：

Tierney, C

Lathey, JL

Christopherson, C

Bettendorf, DM

D'Aquila, RT

Hammer, SM

Katzenstein, DA

机构：

[1] Harvard Univ, Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA 02115 USA

[2] Massachusetts Gen Hosp, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA USA

[4] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[5] Roche Mol Syst, Alameda, CA USA

[6] Stanford Univ, Dept Med, Palo Alto, CA 94304 USA

[7] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2003年 / 187卷 / 01期

关键词：

D O I：

10.1086/345870

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus (HIV) type 1 DNA assay data were obtained at baseline from 111 HIV-1-positive subjects who were treated with nucleosides. Higher baseline DNA level, HIV-1 RNA level, and infectious titer were comparably associated with an increased hazard of disease progression (each P < .03). Only DNA level was significantly associated with survival (adjusted hazard ratio for 1 log(10) higher level, 3.99; 95% confidence interval, 1.44-11.09; P = .008).

引用

收藏

页码：144 / 148

页数：5

相关论文

共 16 条

[1] PCR-based assay to quantify human immunodeficiency virus type 1 DNA in peripheral blood mononuclear cells [J].

Christopherson, C ;

Kidane, Y ;

Conway, B ;

Krowka, J ;

Sheppard, H ;

Kwok, S .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (02) :630-634

[2] Latent reservoirs of HIV: Obstacles to the eradication of virus [J].

Chun, TW ;

Fauci, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :10958-10961

[3] Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy [J].

Finzi, D ;

Blankson, J ;

Siliciano, JD ;

Margolick, JB ;

Chadwick, K ;

Pierson, T ;

Smith, K ;

Lisziewicz, J ;

Lori, F ;

Flexner, C ;

Quinn, TC ;

Chaisson, RE ;

Rosenberg, E ;

Walker, B ;

Gange, S ;

Gallant, J ;

Siliciano, RF .

NATURE MEDICINE, 1999, 5 (05) :512-517

[4] A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter [J].

Hammer, SM ;

Katzenstein, DA ;

Hughes, MD ;

Gundacker, H ;

Schooley, RT ;

Haubrich, RH ;

Henry, WK ;

Lederman, MM ;

Phair, JP ;

Niu, M ;

Hirsch, MS ;

Merigan, TC ;

Blaschke, TF ;

Simpson, D ;

McLaren, C ;

Rooney, J ;

Salgo, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (15) :1081-1090

[5] INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS GENE AMPLIFICATION BY HEPARIN [J].

HOLODNIY, M ;

KIM, S ;

KATZENSTEIN, D ;

KONRAD, M ;

GROVES, E ;

MERIGAN, TC .

JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (04) :676-679

[6] The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter [J].

Katzenstein, DA ;

Hammer, SM ;

Hughes, MD ;

Gundacker, H ;

Jackson, JB ;

Fiscus, S ;

Rasheed, S ;

Elbeik, T ;

Reichman, R ;

Japour, A ;

Merigan, TC ;

Hirsch, MS .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (15) :1091-1098

[7] Associations of CCR5, CCR2, and stromal cell-derived factor 1 genotypes with human immunodeficiency virus disease progression in patients receiving nucleoside therapy [J].

Lathey, JL ;

Tierney, C ;

Chang, SYP ;

D'Aquila, RT ;

Bettendorf, DM ;

Alexander, HC ;

Santini, CD ;

Hughes, AM ;

Barroga, CF ;

Spector, SA ;

Landes, JE ;

Hammer, SM ;

Katzenstein, DA .

JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (11) :1402-1411

[8] Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm3 (ACTG 175) [J].

Lathey, JL ;

Hughes, MD ;

Fiscus, SA ;

Pi, T ;

Jackson, JB ;

Rasheed, S ;

Elbeik, T ;

Reichman, R ;

Japour, A ;

D'Aquila, RT ;

Scott, W ;

Griffith, BP ;

Hammer, SM ;

Katzenstein, DA .

JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (03) :617-624

[9] Prognosis in HIV-1 infection predicted by the quantity of virus in plasma [J].

Mellors, JW ;

Rinaldo, CR ;

Gupta, P ;

White, RM ;

Todd, JA ;

Kingsley, LA .

SCIENCE, 1996, 272 (5265) :1167-1170

[10] RAPID AND SIMPLE PCR ASSAY FOR QUANTITATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RNA IN PLASMA - APPLICATION TO ACUTE RETROVIRAL INFECTION [J].

MULDER, J ;

MCKINNEY, N ;

CHRISTOPHERSON, C ;

SNINSKY, J ;

GREENFIELD, L ;

KWOK, S .

JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (02) :292-300