Frontotemporal dementia and motor neurone disease: Overlapping clinic-pathological disorders

被引：120

作者：

Lillo, Patricia ^{[1
]}

Hodges, John R. ^{[1
]}

机构：

[1] Prince Wales Med Res Inst, Randwick, NSW 2031, Australia

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2009年 / 16卷 / 09期

基金：

澳大利亚研究理事会;

关键词：

Frontotemporal dementia; Motor neurone disease; Frontal dysfunction; AMYOTROPHIC-LATERAL-SCLEROSIS; RAPIDLY PROGRESSIVE APHASIA; FRONTAL-LOBE FUNCTION; COGNITIVE IMPAIRMENT; UBIQUITIN PATHOLOGY; SEMANTIC DEMENTIA; TARDBP MUTATIONS; MEMORY DEFICITS; VERBAL FLUENCY; WHOLE-BRAIN;

D O I：

10.1016/j.jocn.2009.03.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Advances in genetics and pathology have supported the idea of a continuum between frontotemporal dementia (FTD) and motor neurone disease (MISID), which is strengthened by the discovery of the trans-activating responsive (Tar) sequence DNA binding protein (TDP-43) as a key component in the underlying pathology of FTD, FTD-MND and sporadic and familial MND patients. MIND is a multisystem disorder associated with cognitive and behavioural changes which in some instances reaches the criteria for FTD, while a proportion of patients with FTD develop frank MIND. We review the overlap between FTD and MND, emphasizing areas of controversy and uncertainty. (C) 2009 Published by Elsevier Ltd.

引用

页码：1131 / 1135

页数：5

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