Dynamic kinetic resolution:: synthesis of optically active α-amino acid derivatives

被引：60

作者：

Brown, SA

Parker, MC

Turner, NJ

机构：

[1] Univ Edinburgh, Dept Chem, Edinburgh Ctr Prot Technol, Edinburgh EH9 3JJ, Midlothian, Scotland

[2] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 08期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0957-4166(00)00108-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学]; 081704 [应用化学];

摘要：

Candida antarctica lipase B (Novozyme) is an effective catalyst for the dynamic kinetic resolution of racemic 2-benzyl-4-substituted-5(4H)-oxazolones, in the presence of an alcohol, yielding optically active N-benzoyl amino acid esters. The reaction has been optimised with respect to the solvent and the effect of a catalytic amount of organic base is investigated. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：1687 / 1690

页数：4

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