Where Are We With Adjuvant Therapy of Stage III and IV Melanoma in 2009?

被引:17
作者
Fecher, Leslie A. [1 ]
Flaherty, Keith T. [1 ]
机构
[1] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
来源
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2009年 / 7卷 / 03期
关键词
Adjuvant; melanoma; interferon; pegylated; HIGH-RISK MELANOMA; ACTIVE SPECIFIC IMMUNOTHERAPY; COOPERATIVE-ONCOLOGY-GROUP; AMERICAN-JOINT-COMMITTEE; HIGH-DOSE INTERFERON; PHASE-III; METASTATIC MELANOMA; CUTANEOUS MELANOMA; MALIGNANT-MELANOMA; SURGICAL ADJUVANT;
D O I
10.6004/jnccn.2009.0022
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Adjuvant therapy options for advanced melanoma in 2009 remain active observation, high-dose interferon, or clinical trial participation. Close observation is currently the only required adjuvant management, with the purpose of detecting the emergence of regional or metastatic disease early, when surgical management may still be possible. The National Comprehensive Cancer Network guidelines for the workup and,follow-up of all stages of melanoma must, be tailored to specific patients by the treating physician. This article explores the factors to consider when individualizing care within the scope of these guidelines. (JNCCN 2009;7:295-304)
引用
收藏
页码:295 / 304
页数:10
相关论文
共 63 条
[11]  
COIT D, 2008, NCCN CLIN PRACTICE G
[12]   RANDOMIZED, SURGICAL ADJUVANT CLINICAL-TRIAL OF RECOMBINANT INTERFERON ALFA-2A IN SELECTED PATIENTS WITH MALIGNANT-MELANOMA [J].
CREAGAN, ET ;
DALTON, RJ ;
AHMANN, DL ;
JUNG, SH ;
MORTON, RF ;
LANGDON, RM ;
KUGLER, J ;
RODRIGUE, LJ .
JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (11) :2776-2783
[13]   Distinct sets of genetic alterations in melanoma [J].
Curtin, JA ;
Fridlyand, J ;
Kageshita, T ;
Patel, HN ;
Busam, KJ ;
Kutzner, H ;
Cho, KH ;
Aiba, S ;
Bröcker, EB ;
LeBoit, PE ;
Pinkel, D ;
Bastian, BC .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (20) :2135-2147
[14]   Somatic activation of KIT in distinct subtypes of melanoma [J].
Curtin, John A. ;
Busam, Klaus ;
Pinkel, Daniel ;
Bastian, Boris C. .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (26) :4340-4346
[15]   Phenotypic and functional analysis of dendritic cells and clinical outcome in patients with high-risk melanoma treated with adjuvant granulocyte macrophage colony-stimulating factor [J].
Daud, Adil I. ;
Mirza, Noweeda ;
Lenox, Brianna ;
Andrews, Stephanie ;
Urbas, Patricia ;
Gao, Gui X. ;
Lee, Ji-Hyun ;
Sondak, Vernon K. ;
Riker, Adam I. ;
DeConti, Ronald C. ;
Gabrilovich, Dmitry .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (19) :3235-3241
[16]   Detection of melanoma micrometastases in sentinel nodes - The cons [J].
de Wilt, Johannes H. W. ;
van Akkooi, Alexander C. J. ;
Verhoef, Cornelis ;
Eggermont, Alexander M. M. .
SURGICAL ONCOLOGY-OXFORD, 2008, 17 (03) :175-181
[17]   EORTC 18961: Post-operative adjuvant ganglioside GM2-KLH21 vaccination treatment vs observation in stage II (T3-T4N0M0) melanoma: 2nd interim analysis led to an early disclosure of the results [J].
Eggermont, A. M. ;
Suciu, S. ;
Ruka, W. ;
Marsden, J. ;
Testori, A. ;
Corrie, P. ;
Aamdal, S. ;
Ascierto, P. A. ;
Patel, P. ;
Spatz, A. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
[18]   Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma:: final results of EORTC 18991, a randomised phase III trial [J].
Eggermont, Alexander M. M. ;
Suciu, Stefan ;
Santinami, Mario ;
Testori, Alessandro ;
Kruit, Wim H. J. ;
Marsden, Jeremy ;
Punt, Cornelis J. A. ;
Sales, Francois ;
Gore, Martin ;
MacKie, Rona ;
Kusic, Zvonko ;
Dummer, Reinhard ;
Hauschild, Axel ;
Musat, Elena ;
Spatz, Alain ;
Keilholz, Ulrich .
LANCET, 2008, 372 (9633) :117-126
[19]   Contemporary surgical treatment of advanced-stage melanoma [J].
Essner, R ;
Lee, JH ;
Wanek, LA ;
Itakura, H ;
Morton, DL .
ARCHIVES OF SURGERY, 2004, 139 (09) :961-966
[20]  
FECHER L, 2008, MELANOMA TRANSLATION