Cell Fusion as a Hidden Force in Tumor Progression

被引：164

作者：

Lu, Xin ^{[1
]}

Kang, Yibin ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

CANCER RESEARCH | 2009年 / 69卷 / 22期

基金：

美国国家卫生研究院;

关键词：

CHROMOSOME; BONE; ORGANOTROPISM; TETRAPLOIDY; METASTASIS; CARCINOMA; VIRUSES; HYBRIDS;

D O I：

10.1158/0008-5472.CAN-09-2159

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell fusion plays an essential role in fertilization, formation of placenta, bone and muscle tissues, immune response, tissue repair, and regeneration. Increasing recognition of cell fusion in somatic cell dynamics has revitalized the century-old hypothesis that cell fusion may contribute to the initiation and progression of cancer. In this review, we discuss findings from experimental and clinical studies that suggest a potentially multifaceted involvement of cell fusion in different stages of tumor progression, including aneuploidy and tumor initiation, origin of cancer stem cells, multidrug resistance, and the acquisition and diversification of metastatic abilities. [Cancer Res 2009;69(22):8536-9]

引用

收藏

页码：8536 / 8539

页数：4

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