p53: A New Kingpin in the Stem Cell Arena

被引：19

作者：

Aparicio, Samuel ^{[2
]}

Eaves, Connie J. ^{[1
,3
,4
,5
]}

机构：

[1] Univ British Columbia, British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada

[2] Univ British Columbia, Dept Mol Oncol, Vancouver, BC V5Z 1L3, Canada

[3] Univ British Columbia, Dept Pathol, Vancouver, BC V5Z 1L3, Canada

[4] Univ British Columbia, Dept Lab Med, Vancouver, BC V5Z 1L3, Canada

[5] Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 1L3, Canada

来源：

CELL | 2009年 / 138卷 / 06期

关键词：

MAMMARY; GENERATION; PATHWAY;

D O I：

10.1016/j.cell.2009.09.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Identifying new regulators of the stem cell state offers potential for future gains in biomedicine. Evidence that the tumor suppressor p53 is a key regulator of the stem cell state (Cicalese et al., 2009) suggests a broad role for this protein and its pathways in the control of normal tissue homeostasis and tumor formation.

引用

页码：1060 / 1062

页数：4

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