Opposite effects of one session of 1 Hz rTMS on functional connectivity between pre-supplementary motor area and putamen depending on the dyskinesia state in Parkinson's disease

被引：16

作者：

Flamez, Anja ^{[1
]}

Wu, Guo-Rong ^{[2
]}

Wiels, Wietse ^{[1
]}

Van Schuerbeek, Peter ^{[3
]}

De Mey, Johan ^{[3
]}

De Keyser, Jacques ^{[1
]}

Baeken, Chris ^{[4
,5
,6
,7
]}

机构：

[1] Vrije Univ Brussel VUB, Dept Neurol, UZ Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium

[2] Southwest Univ, Fac Psychol, Key Lab Cognit & Personal, Chongqing, Peoples R China

[3] Vrije Univ Brussel VUB, Dept Radiol, UZ Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium

[4] Vrije Univ Brussel VUB, Dept Psychiat, UZ Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium

[5] Univ Ghent, Dept Head & Skin, C Heymanslaan 10, B-9000 Ghent, Belgium

[6] Univ Ghent, GHEP Lab, C Heymanslaan 10, B-9000 Ghent, Belgium

[7] Eindhoven Univ Technol, Dept Elect Engn, Eindhoven, Netherlands

来源：

CLINICAL NEUROPHYSIOLOGY | 2021年 / 132卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Pre-SMA; Parkinson?s disease; LF rTMS; LEVODOPA-INDUCED DYSKINESIAS; THETA-BURST STIMULATION; RESTING-STATE; PLASTICITY; CEREBELLUM; CORTEX; NETWORK; MRI;

D O I：

10.1016/j.clinph.2020.12.024

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: To explore the effects of low-frequency repetitive transcranial magnetic stimulation (LF rTMS) on cortico-striatal-cerebellar resting state functional connectivity in Parkinson's disease (PD), with and without dyskinesias. Methods: Because there is increasing evidence of an involvement of the pre-supplementary motor area (pre-SMA) in the pathophysiology of levodopa induced dyskinesias, we targeted the right pre-SMA with LF rTMS in 17 PD patients. We explored the effects of one sham-controlled LF rTMS session on resting state functional connectivity of interconnected brain regions by using functional MRI, and how it is mod-ified by levodopa. The clinical effect on motor function and dyskinesias was documented. Results: As expected, one LF rTMS session did not alleviate dyskinesias. However, real, and not sham LF rTMS significantly increased the functional connectivity with the right putamen in patients with dyski-nesias. In patients without dyskinesias, the real LF rTMS session significantly decreased functional con-nectivity in the right putamen and the cerebellum. We found no effects on functional connectivity after levodopa ingestion. Conclusion: One session of 1 Hz rTMS has opposing effects on pre-SMA functional connectivity depending on the PD patients' dyskinesia state. Significance: Patients dyskinesias state determines the way LF rTMS affects functional connectivity in late stage PD.

引用

页码：851 / 856

页数：6

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