Homocysteine and risk of open-angle glaucoma

被引：86

作者：

Bleich, S

Jünemann, A

von Ahsen, N

Lausen, B

Ritter, K

Beck, G

Naumann, GOH

Kornhuber, J

机构：

[1] Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Dept Ophthalmol, D-91054 Erlangen, Germany

[3] Univ Erlangen Nurnberg, Univ Eye Hosp, D-91054 Erlangen, Germany

[4] Univ Erlangen Nurnberg, Dept Med Informat, D-91054 Erlangen, Germany

[5] Univ Gottingen, Dept Clin Chem, D-3400 Gottingen, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2002年 / 109卷 / 12期

关键词：

glaucoma; homocysteine; MTHFR polymorphism; glaucomatous optic neuropathy;

D O I：

10.1007/s007020200097

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Homocysteine levels and the frequency of heterozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation are increased in open-angle glaucoma. Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have important implications for understanding glaucomatous optic neuropathy.

引用

页码：1499 / 1504

页数：6

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