Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rγnull Mice Engrafted with Human Erythrocytes

被引：151

作者：

Belen Jimenez-Diaz, Maria ^{[1
]}

Mulet, Teresa ^{[1
]}

Viera, Sara ^{[1
]}

Gomez, Vanessa ^{[1
]}

Garuti, Helen ^{[1
]}

Ibanez, Javier ^{[1
]}

Alvarez-Doval, Angela ^{[1
]}

Shultz, Leonard D. ^{[2
]}

Martinez, Antonio ^{[1
]}

Gargallo-Viola, Domingo ^{[1
]}

Angulo-Barturen, Inigo ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, ID CEDD Dis Developing World, Tres Cantos 28760, Spain

[2] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 10期

关键词：

BIOMEDICAL-RESEARCH; SELECTION;

D O I：

10.1128/AAC.00519-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2R gamma(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid beta 2microglobulin(null) mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc(1).

引用

页码：4533 / 4536

页数：4

共 14 条

[1] A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes [J].

Angulo-Barturen, Inigo ;

Belen Jimenez-Diaz, Maria ;

Mulet, Teresa ;

Rullas, Joaquin ;

Herreros, Esperanza ;

Ferrer, Santiago ;

Jimenez, Elena ;

Mendoza, Alfonso ;

Regadera, Javier ;

Rosenthal, Philip J. ;

Bathurst, Ian ;

Pompliano, David L. ;

Gomez de las Heras, Federico ;

Gargallo-Viola, Domingo .

PLOS ONE, 2008, 3 (05)

[2] A MOUSE MODEL FOR HUMAN MALARIA ERYTHROCYTIC STAGES [J].

BADELL, E ;

PASQUETTO, V ;

VANROOIJEN, N ;

DRUILHE, P .

PARASITOLOGY TODAY, 1995, 11 (06) :235-237

[3]

BLOLAND P, 2003, ASSESSMENT MONITORIN

[4]

Christianson SW, 1997, J IMMUNOL, V158, P3578

[5] Selection of a trioxaquine as an antimalarial drug candidate [J].

Cosledan, Frederic ;

Fraisse, Laurent ;

Pellet, Alain ;

Guillou, Francois ;

Mordmueller, Benjamin ;

Kremsner, Peter G. ;

Moreno, Alicia ;

Mazier, Dominique ;

Maffrand, Jean-Pierre ;

Meunier, Bernard .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (45) :17579-17584

[6] Malaria: progress, perils, and prospects for eradication [J].

Greenwood, Brian M. ;

Fidock, David A. ;

Kyle, Dennis E. ;

Kappe, Stefan H. I. ;

Alonso, Pedro L. ;

Collins, Frank H. ;

Duffy, Patrick E. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (04) :1266-1276

[7] Quantitative Measurement of Plasmodium-Infected Erythrocytes in Murine Models of Malaria by Flow Cytometry Using Bidimensional Assessment of SYTO-16 Fluorescence [J].

Jimenez-Diaz, Maria Belen ;

Mulet, Teresa ;

Gomez, Vanesa ;

Viera, Sara ;

Alvarez, Angela ;

Garuti, Helena ;

Vazquez, Yolanda ;

Fernandez, Alejandra ;

Ibanez, Javier ;

Jimenez, Magdalena ;

Gargallo-Viola, Domingo ;

Angulo-Barturen, Inigo .

CYTOMETRY PART A, 2009, 75A (03) :225-235

[8] The course of infections and pathology in immunomodulated NOD/LtSz-SCID mice inoculated with Plasmodium falciparum laboratory lines and clinical isolates [J].

Moreno, A ;

Ferrer, E ;

Arahuetes, S ;

Eguiluz, C ;

Van Rooijen, N ;

Benito, A .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2006, 36 (03) :361-369

[9] Cross-talk with myeloid accessory cells regulates human natural killer cell interferon-γ responses to malaria [J].

Newman, Kirsty C. ;

Korbel, Daniel S. ;

Hafalla, Julius C. ;

Riley, Eleanor M. .

PLOS PATHOGENS, 2006, 2 (12) :1120-1133

[10]

Pearson T, 2008, CURR TOP MICROBIOL, V324, P25

← 1 2 →