Cellular Elements of the Blood-Brain Barrier

被引：187

作者：

Correale, Jorge ^{[1
,2
]}

Villa, Andres ^{[3
]}

机构：

[1] Inst Neurol Res Dr Raul Carrea FLENI, Dept Neurol, RA-1428 Buenos Aires, DF, Argentina

[2] Austral Univ, Sch Biomed Sci, RA-1428 Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Sch Med, Jose Maria Ramos Mejia Hosp, Dept Neurol, RA-1221 Buenos Aires, DF, Argentina

来源：

NEUROCHEMICAL RESEARCH | 2009年 / 34卷 / 12期

关键词：

Blood brain barrier; Transport; Endothelial cells; Astrocytes; Perycites; Basement membrane matrix; JUNCTIONAL ADHESION MOLECULE; TIGHT-JUNCTION; ENDOTHELIAL-CELLS; IMMUNOGLOBULIN SUPERFAMILY; P-GLYCOPROTEIN; PERIVASCULAR MACROPHAGES; ORTHOGONAL ARRAYS; WATER TRANSPORT; PDGF-B; OCCLUDIN;

D O I：

10.1007/s11064-009-0081-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Blood-brain-barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), shielding the brain for toxic substances in the blood, supplying brain tissues with nutrients and filtering harmful compounds from the brain back to the bloodstream. The BBB is composed of four main cellular elements: endothelial cells (ECs), astrocyte end-feet, microglial cells, and perycites. Transport across the BBB is limited by both physical and metabolic barriers (enzymes, and different transport systems). Tight junctions (TJs) present between ECs form an important barrier against diffusion, excluding most blood-borne substances for entering the brain.

引用

页码：2067 / 2077

页数：11

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