Protective Effect of Millettia reticulata Benth Against CCl4-Induced Hepatic Damage and Inflammatory Action in Rats

被引：16

作者：

Hsu, Chien-Chen ^{[1
]}

Hsu, Chin-Lin ^{[2
]}

Tsai, Shao-En ^{[1
]}

Fu, Timothy Yu-Chi ^{[3
]}

Yen, Gow-Chin ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Food Sci & Biotechnol, Taichung 402, Taiwan

[2] Chung Shan Med Univ, Sch Nutr, Taichung, Taiwan

[3] Jen Ai Gen Hosp, Dept Obstet & Gynecol, Taichung, Taiwan

来源：

JOURNAL OF MEDICINAL FOOD | 2009年 / 12卷 / 04期

关键词：

carbon tetrachloride; hepatic damage; inflammation; Millettia reticulata Benth; protocatechuic acid; EUCOMMIA-ULMOIDES OLIV; NITRIC-OXIDE; OXIDATIVE STRESS; LIVER; NITRATE; ACID;

D O I：

10.1089/jmf.2008.1227

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effects of the water extracts of Millettia reticulata Benth (WEMRB) and its active compound ( protocatechuic acid [PCA]) on acute hepatic injury and inflammation in CCl4-induced Sprague-Dawley rats were investigated. Sprague-Dawley rats were orally treated with WEMRB or PCA for 28 consecutive days, and then the rats were given an intraperitoneal injection with CCl4. Pretreatment with WEMRB or PCA significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (aspartate and alanine aminotransferases). Liver histopathology showed that WEMRB reduced the incidence of cytoplasmic vacuolization and necrosis induced by CCl4 in rats. Pretreatment with WEMRB also showed anti-inflammation on the expression of cyclooxygenase-2, inducible nitric oxide synthase, and myeloperoxidase, as well as nitrite and nitrate levels in the CCl4-induced Sprague-Dawley rats. The results suggest that oral administration of WEMRB decreases the hepatotoxic effects by increasing glutathione-dependent antioxidant enzyme activity, thereby reducing oxidative stress and inflammation in CCl4-induced Sprague-Dawley rats.

引用

页码：821 / 828

页数：8

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