3,4,5-trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica bioassay guided activity

被引:92
作者
Anand, KK
Singh, B
Saxena, AK
Chandan, BK
Gupta, VN
Bhardwaj, V
机构
[1] REG RES LAB,DIV NAT PROD CHEM,JAMMU 180001,INDIA
[2] REG RES LAB,DIV PHARMACOL,JAMMU 180001,INDIA
关键词
Terminalia belerica; bioassay guided activity; hepatoprotective activity; CCl4; induced hepatotoxicity;
D O I
10.1006/phrs.1997.0236
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Compound I isolated from fraction TB5 of Terminalia belerica and finally identified as 3,4,5-trihydroxy benzoic acid (gallic acid) was evaluated for its hepatoprotective activity against carbon tetrachloride (CCl4)-induced physiological and biochemical alterations in the liver. The main parameters studied were hexobarbitone-induced sleep, zoxazolamine induced paralysis, serum levels of. transaminases and bilirubin. The hepatic markers assessed were lipid peroxidation, drug metabolising enzymes, glucose-6-phosphatase and triglycerides. Administration of Compound I led to significant reversal of majority of the altered parameters. Our results confirm the presence of hepatoprotective activity in Compound I. (C) 1997 The Italian Pharmacological Society.
引用
收藏
页码:315 / 321
页数:7
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