Enteric defensins are essential regulators of intestinal microbial ecology

被引：910

作者：

Salzman, Nita H. ^{[1
,4
]}

Hung, Kuiechun ^{[1
,4
]}

Haribhai, Dipica ^{[2
,3
,4
]}

Chu, Hiutung ^{[5
]}

Karlsson-Sjoeberg, Jenny ^{[5
]}

Amir, Elad ^{[1
,4
]}

Teggatz, Paul ^{[1
,4
]}

Barman, Melissa ^{[1
,4
]}

Hayward, Michael ^{[1
,4
]}

Eastwood, Daniel ^{[6
]}

Stoel, Maaike ^{[7
]}

Zhou, Yanjiao ^{[8
]}

Sodergren, Erica ^{[8
]}

Weinstock, George M. ^{[8
]}

Bevins, Charles L. ^{[5
]}

Williams, Calvin B. ^{[2
,3
,4
]}

Bos, Nicolaas A. ^{[7
]}

机构：

[1] Med Coll Wisconsin, Div Gastroenterol, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Div Rheumatol, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA

[4] Med Coll Wisconsin, Childrens Res Inst, Milwaukee, WI 53226 USA

[5] Univ Calif Davis, Sch Med, Dept Microbiol & Immunol, Davis, CA 95616 USA

[6] Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA

[7] Univ Groningen, Univ Med Ctr Groningen, Immunol Sect, Dept Cell Biol, NL-9700 AB Groningen, Netherlands

[8] Washington Univ, Sch Med, Dept Genet, Genome Ctr, St Louis, MO 63110 USA

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SEGMENTED FILAMENTOUS BACTERIA; DISTAL GUT MICROBIOME; PANETH CELL; ANTIMICROBIAL PEPTIDES; IMMUNE-RESPONSE; INNATE IMMUNITY; MOUSE; DISEASE; MICE; COLONIZATION;

D O I：

10.1038/ni.1825

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antimicrobial peptides are important effectors of innate immunity throughout the plant and animal kingdoms. In the mammalian small intestine, Paneth cell alpha-defensins are antimicrobial peptides that contribute to host defense against enteric pathogens. To determine if alpha-defensins also govern intestinal microbial ecology, we analyzed the intestinal microbiota of mice expressing a human alpha-defensin gene (DEFA5) and in mice lacking an enzyme required for the processing of mouse alpha-defensins. In these complementary models, we detected significant alpha-defensin-dependent changes in microbiota composition, but not in total bacterial numbers. Furthermore, DEFA5-expressing mice had striking losses of segmented filamentous bacteria and fewer interleukin 17 (IL-17)-producing lamina propria T cells. Our data ascribe a new homeostatic role to alpha-defensins in regulating the makeup of the commensal microbiota.

引用

页码：76 / U1

页数：8

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