Decomposition of cocoa procyanidins in the gastric milieu

被引：218

作者：

Spencer, JPE

Chaudry, F

Pannala, AS

Srai, SK

Debnam, E

Rice-Evans, C

机构：

[1] Kings Coll London, Antioxidant Res Grp, Wolfson Ctr Age Related Dis, GKT Sch Biomed Sci, London SE1 9RT, England

[2] UCL Royal Free & Univ Coll Med Sch, London NW3 2PF, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 272卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

procyanidin; epicatechin; gastric juice; absorption; glucuronide; jejunum; ileum;

D O I：

10.1006/bbrc.2000.2749

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is considerable interest in the bioavailability of flavonoids and phenolic components of the diet and their bioactivity in vivo. However, little is known of pre-absorption events in the gastric lumen. The effects of the acidic environment, as found in the gastric milieu, on procyanidin oligomers of catechin polyphenols has been investigated. The results show that under these conditions the procyanidin oligomers (trimer to hexamer) are hydrolysed to mixtures of epicatechin monomer and dimer, thus enhancing the potential for their absorption in the small intestine. (C) 2000 Academic Press.

引用

页码：236 / 241

页数：6

共 22 条

[1] HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity [J].

Adamson, GE ;

Lazarus, SA ;

Mitchell, AE ;

Prior, RL ;

Cao, GH ;

Jacobs, PH ;

Kremers, BG ;

Hammerstone, JF ;

Rucker, RB ;

Ritter, KA ;

Schmitz, HH .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1999, 47 (10) :4184-4188

[2] Protection against peroxynitrite by cocoa polyphenol oligomers [J].

Arteel, GE ;

Sies, H .

FEBS LETTERS, 1999, 462 (1-2) :167-170

[3]

Bell JRC, 2000, AM J CLIN NUTR, V71, P103

[4]

Bravo L, 1998, NUTR REV, V56, P317, DOI 10.1111/j.1753-4887.1998.tb01670.x

[5]

HACKETT AM, 1986, PLANT FLAVONOIDS BIO, P177

[6] Identification of procyanidins in cocoa (Theobroma cacao) and chocolate using high-performance liquid chromatography mass spectrometry [J].

Hammerstone, JF ;

Lazarus, SA ;

Mitchell, AE ;

Rucker, R ;

Schmitz, HH .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1999, 47 (02) :490-496

[7] Identification of the major antioxidative metabolites in biological fluids of the rat with ingested (+)-catechin and (-)-epicatechin [J].

Harada, M ;

Kan, Y ;

Naoki, H ;

Fukui, Y ;

Kageyama, N ;

Nakai, M ;

Miki, W ;

Kiso, Y .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1999, 63 (06) :973-977

[8]

HIGUCHI WI, 1981, DRUG ABSORPTION, P35

[9]

Ho N. F. H., 1983, Animal Models for Oral Drug Delivery in Man: In Situ and In Vitro Approaches, P27

[10] Inhibition of LDL oxidation by cocoa [J].

Kondo, K ;

Hirano, R ;

Matsumoto, A ;

Igarashi, O ;

Itakura, H .

LANCET, 1996, 348 (9040) :1514-1514

← 1 2 3 →