Determination of cocaine and cocaethylene in plasma by solid-phase microextraction and gas chromatography-mass spectrometry

被引：35

作者：

Alvarez, Ivan ^{[1
]}

Bermejo, Ana Maria ^{[1
]}

Tabernero, Maria Jesus ^{[1
]}

Fernandez, Purificacion ^{[1
]}

Lopez, Patricia ^{[1
]}

机构：

[1] Fac Med, Forens Toxicol Serv, Inst Legal Med, Santiago De Compostela 15782, Spain

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2007年 / 845卷 / 01期

关键词：

cocaine; cocaethylene; solid-phase microextraction; gas chromatography-mass spectrometry;

D O I：

10.1016/j.jchromb.2006.07.061

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The present paper describes a method for the simultaneous determination of cocaine and cocaethylene in plasma. It was based in the extraction of the analytes by solid-phase microextraction (SPME), and gas chromatography-mass spectrometry (GC-MS) was used to identify and quantify the analytes in selected ion monitoring (SIM) mode. The method showed to be very simple, rapid and sensitive. The method was validated for the two compounds, including linearity (range 25-1000 ng/mL) and the main precision parameters. It was applied to ten plasma samples from cocaine and alcohol users, obtaining positive results in all cases. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：90 / 94

页数：5

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