Slicer and the Argonautes

被引：328

作者：

Tolia, Niraj H. ^{[1
]}

Joshua-Tor, Leemor ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, WM Keck Struct Biol Lab, Cold Spring Harbor, NY 11724 USA

来源：

NATURE CHEMICAL BIOLOGY | 2007年 / 3卷 / 01期

关键词：

D O I：

10.1038/nchembio848

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Though they started out as somewhat mysterious components of the RNAi effector complexes, Argonaute proteins have since taken center stage in RNAi gene silencing. They interact with small RNAs to effect gene silencing in all RNAi-related pathways known so far. We will review the dramatic advances in our understanding of the role of the Argonautes in RNAi through studies of their structure and function.

引用

页码：36 / 43

页数：8