Synthesis and properties of oligoribonucleotide analogues having amide (3'-CH2-CO-NH-5') internucleoside linkages

被引：11

作者：

Rozners, E ^{[1
]}

Stromberg, R ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS,ORGAN & BIOORGAN CHEM LAB,S-17177 STOCKHOLM,SWEDEN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期

关键词：

D O I：

10.1080/07328319708006117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amide linked ribonucleoside dimer 5 was prepared and converted into selectively protected H-phosphonate building block 9. Oligoribonucleotide duplexes having amide linkages at selected sites were synthesized and their stability was studied by UV melting experiments.

引用

页码：967 / 970

页数：4

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