Development of a gene transfer-based treatment for radiation-induced salivary hypofunction

被引：42

作者：

Baum, Bruce J. ^{[1
]}

Zheng, Changyu ^{[1
]}

Alevizos, Ilias ^{[1
]}

Cotrim, Ana P. ^{[1
]}

Liu, Shuying ^{[1
]}

McCullagh, Linda ^{[1
]}

Goldsmith, Corinne M. ^{[1
]}

McDermott, Nancy

Chiorini, John A. ^{[1
]}

Nikolov, Nikolay P. ^{[1
]}

Illei, Gabor G. ^{[1
]}

机构：

[1] NIDCR, MPTB, NIH, Bethesda, MD 20892 USA

来源：

ORAL ONCOLOGY | 2010年 / 46卷 / 01期

关键词：

Xerostomia; Radiation; Gene therapy; Aquaporin-1; Adenovirus; Oral cancer; ADENOVIRAL-MEDIATED TRANSFER; INCREASED FLUID SECRETION; HUMAN AQUAPORIN-1 CDNA; PAROTID-GLANDS; TRANSFER VECTORS; LOCAL-DELIVERY; TOXICITY; CANCER; HEAD; INDIVIDUALS;

D O I：

10.1016/j.oraloncology.2009.09.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

A significant long-term side effect of radiation therapy for head and neck cancers is xerostomia, a dry mouth, due to salivary gland damage. Despite continuing efforts to eliminate this problem, many patients continue to suffer. This brief review describes our efforts to develop a gene transfer approach, employing the aquaporin-1 cDNA, to treat patients with existing radiation-induced salivary hypofunction. A Phase I/II clinical trial, using a recombinant adenoviral vector to mediate gene transfer, is currently underway. Published by Elsevier Ltd.

引用

页码：4 / 8

页数：5

共 38 条

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MORPHOLOGIC AND HISTOCHEMICAL-STUDIES ON THE DIFFERING RADIOSENSITIVITY OF DUCTULAR AND ACINAR-CELLS OF THE RAT SUBMANDIBULAR-GLAND [J].