Adhesion molecules in haemopoiesis

In the adult mammal, haemopoiesis is restricted to the extravascular compartment of the bone marrow (BM) where primitive haemopoietic stem cells (HSC) and their clonogenic progeny develop in intimate contiguity with a heterogeneous population of stromal cells that comprise the haemopoietic micro-environment (HM). Although the importance of cellular interactions between primitive haemopoietic progenitor cells (HPC) and marrow stromal cells is well established, precise definition of the nature of many of these interactions at the molecular level is lacking and remains an objective of fundamental importance to understanding of haemopoietic regulation. Current data suggest that a wide variety of cell surface molecules representing several adhesion molecule superfamilies, including integrins, selectins, sialomucins and the immunoglobulin gene superfamily, are involved in supporting cell-cell and cell-extracellular matrix (ECM) interactions. These diverse CAM-ligand interactions, rather than simply serving to initiate and maintain contact between HPC and stromal cells and ECM components, also have an additional, more direct role in controlling the growth and development of primitive haemopoietic cells.