RecA force generation by hydrolysis waves

被引：8

作者：

Klapstein, K ^{[1
]}

Bruinsma, R

机构：

[1] Univ Calif Los Angeles, Dept Biomath, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Phys & Astron, Los Angeles, CA 90095 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2000年 / 275卷 / 21期

关键词：

D O I：

10.1074/jbc.275.21.16073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a simple theory of the dynamics of force generation by RecA during homologous strand exchange and a continuous, deterministic mathematical model of the proposed process. Calculations show that force generation is possible in this model for certain reasonable values of the parameters. We predict the shape of the force-velocity curve for the Holliday junction, which exhibits a distinctive kink at large retarding force, and suggest experiments which should distinguish between the proposed model and other models in the literature.

引用

页码：16073 / 16083

页数：11

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