Dysoxylins A-D, tetranortriterpenoids with potent anti-RSV activity from Dysoxylum gaudichaudianum

被引：32

作者：

Chen, Jian Lu ^{[1
]}

Kernan, Michael R. ^{[1
]}

Jolad, Shivanand D. ^{[1
]}

Stoddart, Cheryl A. ^{[1
]}

Bogan, Mark ^{[1
]}

Cooper, Raymond ^{[1
]}

机构：

[1] Shaman Pharmaceut, San Francisco, CA 94080 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 02期

关键词：

D O I：

10.1021/np060398y

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Four new compunds, belonging to the tetranortriterpenoid family, named dysoxylins A-D (1-4), isolated from Dysoxylum gaudichaudianum, were found to exhibit potent antiviral activity against respiratory syncytial virus (RSV). These structures were determined by NMR spectroscopy and mass spectrometry and were shown to have anti-RSV EC50 activities in the range 1.0-4.0 mu g/mL in cytopathic effect inhibition and plaque reduction assays.

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页码：312 / 315

页数：4

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