The synthesis of three new heterocycles:: the pyrido[4,3 or 3,4 or 2,3-c]-1,5-naphthyridines

被引：20

作者：

Cailly, Thomas

Fabis, Frederic

Legay, Remi

Oulyadi, Hassan

Rault, Sylvain ^{[1
]}

机构：

[1] Univ Caen, Ctr Etud & Rech Medicament Normandie, UFR Sci Pharmaceut, F-14032 Caen, France

[2] Univ Rouen, Lab RMN, IRCOF, UMR 6014,CNRS, F-76821 Mont St Aignan, France

来源：

TETRAHEDRON | 2007年 / 63卷 / 01期

关键词：

D O I：

10.1016/j.tet.2006.10.046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrido[4,3 or 3,4 or 2,3-c]-1,5-naphthyridines were obtained with good yields after chlorodehydroxylation and dehalogenation reactions starting from the parent pyridonaphthyridinones. These pyridonaphthyridinones were synthesized in a two-step procedure using a Suzuki cross-coupling reaction between 2-chloro-3-fluoropyridine and orthocyanopyridylboronic esters followed by a KOH-mediated anionic ring closure. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：71 / 76

页数：6

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