Resveratrol, a natural diphenol, growth in an experimental reduces metastatic cancer model

被引：65

作者：

Busquets, Silvia ^{[1
]}

Ametller, Elisabet ^{[1
]}

Fuster, Gemma ^{[1
]}

Olivan, Mireia ^{[1
]}

Raab, Viktoria ^{[1
]}

Argiles, Josep M. ^{[1
]}

Lopez-Soriano, Francisco J. ^{[1
]}

机构：

[1] Univ Barcelona, Fac Biol, Canc Res Grp, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain

来源：

CANCER LETTERS | 2007年 / 245卷 / 1-2期

关键词：

resveratrol; anti-metastatic; tumour growth;

D O I：

10.1016/j.canlet.2005.12.035

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Administration of different doses of the diphenol resveratrol had no effect on the growth of an intramuscularly implanted experimental tumour, the Lewis lung carcinoma. These results do not agree with previous reports where a clear effect of resveratrol was shown on tumour burden in both mice and rats. However, administration of the diphenol had a clear anti-metastatic effect, decreasing both the number and the weight of the lung metastases. Similar effects were observed both at 5 and 25 mg/kg body weight per day, resulting in an approximately 40% reduction in the number of metastases. These results suggest that resveratrol could be tentatively given as a preventive agent in cancer patients undergoing radiotherapy or chemotherapy. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：144 / 148

页数：5

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