How the Listeria monocytogenes ActA protein converts actin polymerization into a motile force

被引：32

作者：

Smith, GA ^{[1
]}

Portnoy, DA ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT MICROBIOL,PHILADELPHIA,PA 19104

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 07期

关键词：

D O I：

10.1016/S0966-842X(97)01048-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ActA protein is an essential determinant of pathogenicity that is responsible for the actin-based motility of Listeria monocytogenes in mammalian cells and cell-free extracts. ActA appears to control at least four functions that collectively lead to actin-based motility: (1) initiation of actin polymerization, (2) polarization of ActA function, (3) transformation of actin polymerization into a motile force and (4) acceleration of movement mediated by the host protein profilin.

引用

页码：272 / 276

页数：5

共 42 条

[1] ARMSTRONG D, 1990, PRINCIPLES PRACTICE, P1587
[2] EXPRESSION AND PHOSPHORYLATION OF THE LISTERIA-MONOCYTOGENES ACTA PROTEIN IN MAMMALIAN-CELLS
BRUNDAGE, RA
SMITH, GA
CAMILLI, A
THERIOT, JA
PORTNOY, DA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) : 11890 - 11894
[3] A FOCAL ADHESION FACTOR DIRECTLY LINKING INTRACELLULARLY MOTILE LISTERIA-MONOCYTOGENES AND LISTERIA-IVANOVII TO THE ACTIN-BASED CYTOSKELETON OF MAMMALIAN-CELLS
CHAKRABORTY, T
EBEL, F
DOMANN, E
NIEBUHR, K
GERSTEL, B
PISTOR, S
TEMMGROVE, CJ
JOCKUSCH, BM
REINHARD, M
WALTER, U
WEHLAND, J
[J]. EMBO JOURNAL, 1995, 14 (07) : 1314 - 1321
[4] THE ACTIN-BASED MOTILITY OF THE FACULTATIVE INTRACELLULAR PATHOGEN LISTERIA-MONOCYTOGENES
COSSART, P
KOCKS, C
[J]. MOLECULAR MICROBIOLOGY, 1994, 13 (03) : 395 - 402
[5] ACTIN-BASED BACTERIAL MOTILITY
COSSART, P
[J]. CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (01) : 94 - 101
[6] LISTERIA-MONOCYTOGENES MOVES RAPIDLY THROUGH THE HOST-CELL CYTOPLASM BY INDUCING DIRECTIONAL ACTIN ASSEMBLY
DABIRI, GA
SANGER, JM
PORTNOY, DA
SOUTHWICK, FS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) : 6068 - 6072
[7] A NOVEL BACTERIAL VIRULENCE GENE IN LISTERIA-MONOCYTOGENES REQUIRED FOR HOST-CELL MICROFILAMENT INTERACTION WITH HOMOLOGY TO THE PROLINE-RICH REGION OF VINCULIN
DOMANN, E
WEHLAND, J
ROHDE, M
PISTOR, S
HARTL, M
GOEBEL, W
LEIMEISTERWACHTER, M
WUENSCHER, M
CHAKRABORTY, T
[J]. EMBO JOURNAL, 1992, 11 (05) : 1981 - 1990
[8] TARGETING OF LISTERIA-MONOCYTOGENES ACTA PROTEIN TO THE PLASMA-MEMBRANE AS A TOOL TO DISSECT BOTH ACTIN-BASED CELL MORPHOGENESIS AND ACTA FUNCTION
FRIEDERICH, E
GOUIN, E
HELLIO, R
KOCKS, C
COSSART, P
LOUVARD, D
[J]. EMBO JOURNAL, 1995, 14 (12) : 2731 - 2744
[9] Mena, a relative of VASP and Drosophila enabled, is implicated in the control of microfilament dynamics
Gertler, FB
Niebuhr, K
Reinhard, M
Wehland, J
Soriano, P
[J]. CELL, 1996, 87 (02) : 227 - 239
[10] KOCKS C, 1993, J CELL SCI, V105, P699

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