How the Listeria monocytogenes ActA protein converts actin polymerization into a motile force

被引：32

作者：

Smith, GA ^{[1
]}

Portnoy, DA ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT MICROBIOL,PHILADELPHIA,PA 19104

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 07期

关键词：

D O I：

10.1016/S0966-842X(97)01048-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ActA protein is an essential determinant of pathogenicity that is responsible for the actin-based motility of Listeria monocytogenes in mammalian cells and cell-free extracts. ActA appears to control at least four functions that collectively lead to actin-based motility: (1) initiation of actin polymerization, (2) polarization of ActA function, (3) transformation of actin polymerization into a motile force and (4) acceleration of movement mediated by the host protein profilin.

引用

页码：272 / 276

页数：5

共 42 条

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