Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster

被引：50

作者：

Plongthongkum, Nongluk

Kullawong, Niwed

Panyim, Sakol

Tirasophon, Witoon ^{[1
]}

机构：

[1] Mahidol Univ, Inst Mol Biol & Genet, Salaya 73170, Nakhonpathom, Thailand

[2] Mahidol Univ, Fac Sci, Dept Biochem, Bangkok 10400, Thailand

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 354卷 / 03期

关键词：

unfolded protein response (UPR); endoplasmic reticulum (ER); inositol required 1 (Ire1); X-box binding protein (XBP1); Drosophila melanogaster;

D O I：

10.1016/j.bbrc.2007.01.056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of cells to survive and recover from deteriorating effects of endoplasmic reticulum (ER) stress relies on the unfolded protein response (UPR). The signaling pathway of Ire1p mediate mRNA splicing plays diverge role in UPR response in different organisms from yeast to mammals. Here, we report that Ire1p mediated XBP1 mRNA splicing mechanism is extremely conserved and exerts a critical role for modulating Xbp1 protein synthesis in Drosophila melanogaster. This system is operative in Drosophila S2 cells as a prominent mechanism to mediate transcriptional activation of UPR responsive genes during ER stress. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：789 / 794

页数：6

共 22 条

[1] A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response [J].