Small-molecule regulation of zebrafish gene expression

被引：57

作者：

Esengil, Hanife ^{[1
]}

Chang, Vicky ^{[1
]}

Mich, John K. ^{[1
]}

Chen, James K. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Ctr Clin Sci Res, Stanford, CA 94305 USA

来源：

NATURE CHEMICAL BIOLOGY | 2007年 / 3卷 / 03期

关键词：

D O I：

10.1038/nchembio858

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The zebrafish has emerged as a versatile model organism for biomedical research, yet its potential has been limited by a lack of conditional reverse-genetic tools. Here we report a chemically inducible gene expression technology that has orthogonality to vertebrate signaling processes, high induction levels, and rapid kinetics. Coupled with tissue-specific promoters, this system provides multidimensional control of gene expression and will enable new models of human disorders and diseases.

引用

页码：154 / 155

页数：2