A microwave-assisted heck reaction in poly(ethylene glycol) for the synthesis of benzazepines

被引：40

作者：

Declerck, Valerie

Ribiere, Patrice

Nedellec, Yannig

Allouchi, Hassan

Martinez, Jean

Lamaty, Frederic

机构：

[1] Univ Montpellier I, CNRS, LAPP, F-34095 Montpellier 5, France

[2] Univ Montpellier 2, CNRS, LAPP, F-34095 Montpellier 5, France

[3] Univ Montpellier 2, CNRS, LAMMI, F-34095 Montpellier 5, France

[4] Univ Tours, Fac Pharm, SPOT, EA 3857,Lab Chim Phys, F-37200 Tours, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 2007卷 / 01期

关键词：

microwaves; nitrogen heterocycles; nanoparticles; palladium; solvent effects;

D O I：

10.1002/ejoc.200600680

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Heck reaction of alkylated 2 - (trimethylsilyl) ethane sulfonyl (SES)-protected beta-amino esters provides benzazepines in good yields. Good selectivity towards cyclisation was obtained when the reaction was performed in PEG 3400 as the solvent under microwave activation. Cleavage of the SES group with HF provides the corresponding free benzazepine. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).

引用

页码：201 / 208

页数：8

共 55 条

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