Modified citrus pectin anti-metastatic properties: one bullet, multiple targets

被引：221

作者：

Glinsky, Vladislav V. ^{[1
,2
]}

Raz, Avraham ^{[3
]}

机构：

[1] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA

[2] Univ Missouri, Dept Pathol & Anat Sci, Columbia, MO 65212 USA

[3] Wayne State Univ, Karmanos Canc Inst, Tumor Progress & Metastasis Program, Detroit, MI 48201 USA

来源：

CARBOHYDRATE RESEARCH | 2009年 / 344卷 / 14期

关键词：

Modified citrus pectin; Cancer metastasis; Galectin-3; Adhesion; Apoptosis; PROSTATE-CANCER CELLS; GALECTIN-3 OVEREXPRESSION PROTECTS; HUMAN BREAST; INDUCED APOPTOSIS; THERAPEUTIC TARGET; CARCINOMA CELLS; TUMOR-CELLS; ENDOTHELIUM; ADHESION; METASTASIS;

D O I：

10.1016/j.carres.2008.08.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In this minireview, we examine the ability of modified citrus pectin (MCP), a complex water soluble indigestible polysaccharide obtained from the peel and pulp of citrus fruits and modified by means of high pH and temperature treatment, to affect numerous rate-limiting steps in cancer metastasis. The anti-adhesive properties of MCP as well as its potential for increasing apoptotic responses of tumor cells to chemotherapy by inhibiting galectin-3 anti-apoptotic function are discussed in the light of a potential use of this carbohydrate-based substance in the treatment of multiple human malignancies. Published by Elsevier Ltd.

引用

页码：1788 / 1791

页数：4

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