Immune Activation by Life-Shortening Wolbachia and Reduced Filarial Competence in Mosquitoes

被引：388

作者：

Kambris, Zakaria ^{[1
]}

Cook, Peter E. ^{[1
]}

Phuc, Hoang K. ^{[1
]}

Sinkins, Steven P. ^{[1
]}

机构：

[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

SCIENCE | 2009年 / 326卷 / 5949期

基金：

英国惠康基金;

关键词：

ANOPHELES-GAMBIAE; AEDES-AEGYPTI; DROSOPHILA-MELANOGASTER; ANTIMICROBIAL PEPTIDES; BRUGIA-PAHANGI; PLASMODIUM; COMPLEMENT; INFECTION; SUSCEPTIBILITY; TRANSMISSION;

D O I：

10.1126/science.1177531

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito's innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype.

引用

收藏

页码：134 / 136

页数：3

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