G-protein-coupled receptors and cancer

被引：1009

作者：

Dorsam, Robert T. ^{[1
]}

Gutkind, J. Silvio ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 02期

关键词：

D O I：

10.1038/nrc2069

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis. Malignant cells often hijack the normal physiological functions of GPCRs to survive, proliferate autonomously, evade the immune system, increase their blood supply, invade their surrounding tissues and disseminate to other organs. This Review will address our current understanding of the many roles of GPCRs and their signalling circuitry in tumour progression and metastasis. We will also discuss how interfering with GPCRs might provide unique opportunities for cancer prevention and treatment.

引用

页码：79 / 94

页数：16

共 154 条

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