Local foreign-body reactions to biodegradable implants - A classification system

被引：56

作者：

Hoffmann, R

Weiler, A

Helling, HJ

Krettek, C

Rehm, KE

机构：

[1] Unfall- und Wiederherstellungschirurgie,

[2] Medizinische Fakultät Charité,undefined

[3] Virchow Klinikum,undefined

[4] Humboldt-Universität zu Berlin,undefined

[5] Klinik und Poliklinik für Unfall-,undefined

[6] Hand- und Wiederherstellungschirurgie,undefined

[7] Universität zu Köln,undefined

[8] Unfallchirurgische Klinik,undefined

[9] Medizinische Hochschule Hannover,undefined

来源：

UNFALLCHIRURG | 1997年 / 100卷 / 08期

关键词：

foreign-body reactions; biocompatibility; biodegradable implants; classification; osteolysis;

D O I：

10.1007/s001130050172

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Biodegradable implants are increasingly used in orthopedic and trauma surgery. Many different implants consisting of different biodegradable polymers are currently available. Different factors contribute to the biocompatibility of these implants, and local foreign-body reactions remain a matter of concern. Therefore, it is mandatory to document and compare the tissue reactions caused by various biodegradable implants in experimental or clinical studies. We have developed a standardized system of classification based on our previous experimental and clinical observations. Foreign-body reactions are differentiated into osteolyses (O-0 to O-4), extra-articular (EA-0 to EA-4) and intraarticular (IA-0 to IA-4) soft-tissue reactions.

引用

页码：658 / 666

页数：9

共 76 条

[21]

COHN ZA, 1978, J IMMUNOL, V121, P813

[22]

DANIELS AU, 1992, P ORTHOP RES SOC, V38, P88

[23]

Edwards D J, 1994, J Shoulder Elbow Surg, V3, P230, DOI 10.1016/S1058-2746(09)80040-2

[24]

Eitenmuller J, 1996, CHIRURG, V67, P413