Roles of phospholipase C beta 2 in chemoattractant-elicited responses

被引：124

作者：

Jiang, HP ^{[1
]}

Kuang, YN ^{[1
]}

Wu, YP ^{[1
]}

Xie, W ^{[1
]}

Simon, MI ^{[1
]}

Wu, DQ ^{[1
]}

机构：

[1] CALTECH, DIV BIOL, PASADENA, CA 91125 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 15期

关键词：

D O I：

10.1073/pnas.94.15.7971

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The physiological roles of phospholipase C (PLC) beta 2 in hematopoiesis, leukocyte function, and host defense against infection were investigated using a mouse line that lacks PLC beta 2. PLC beta 2 deficiency did not affect hematopoiesis, but it blocked chemoattractant-induced Ca2+ release, superoxide production, and MAC-1 up-regulation in neutrophils. In view of these effects, it was surprising that the absence of PLC beta 2 enhanced chemotaxis of different leukocyte populations and sensitized the in vivo response of the PLC beta 2-deficient mice to bacteria, viruses, and immune complexes, These data raise questions about the roles that PLC beta 2 may play in signal transduction induced by chemoattractants in leukocytes.

引用

页码：7971 / 7975

页数：5

共 29 条

[21] EFFECT OF THE COMBINATION OF INTERFERON-ALPHA AND STAVUDINE ON FRIEND-VIRUS INFECTIONS IN (B10.A X A.BY)F-1 MICE [J].