ICAM-1 in acute myocardial infarction: A potential therapeutic target

被引：29

作者：

Benson, Victoria

McMahon, Aisling Clare

Lowe, Harry Claude

机构：

[1] Concord Repatriat Gen Hosp, Vasc Biol Lab, ANZAC, Med Res Inst, Concord, NSW 2139, Australia

[2] Concord Repatriat Gen Hosp, Dept Cardiol, Concord, NSW 2139, Australia

来源：

CURRENT MOLECULAR MEDICINE | 2007年 / 7卷 / 02期

关键词：

acute myocardial infarction; ischaemia reperfusion; adhesion molecule;

D O I：

10.2174/156652407780059131

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Current treatments for AMI centre on prompt restoration of epicardial coronary blood flow. Despite improvements, AMI is still associated with significant morbidity and mortality. Novel approaches are therefore keenly sought. Intercellular adhesion molecule-1 (ICAM-1, CD54) is a member of the immunoglobulin superfamily. It is implicated in neutrophil and monocyte-endothelial cell adhesion, processes contributing to myocardial neutrophil infiltration and microvascular coronary slow flow, both viewed as important to the pathophysiologic responses in AMI. ICAM-1 would therefore appear an important potential therapeutic target in this context, and is the subject of this review.

引用

收藏

页码：219 / 227

页数：9

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