Isoprostanes quickly normalize after quitting cigarette smoking in healthy adults

被引：31

作者：

Oguogho, A

Lupattelli, G

Palumbo, B

Sinzinger, H

机构：

[1] Wilhelm Auerswald Atherosclerosis Res Grp ASF, A-1090 Vienna, Austria

[2] Univ Vienna, Dept Nucl Med, A-1010 Vienna, Austria

[3] Univ Perugia, Dept Internal Med, I-06100 Perugia, Italy

[4] Univ Perugia, Inst Nucl Med, I-06100 Perugia, Italy

来源：

VASA-JOURNAL OF VASCULAR DISEASES | 2000年 / 29卷 / 02期

关键词：

cigarette smoking; oxidation injury; isoprostanes; 8-epi-prostaglandin F-2 alpha;

D O I：

10.1024/0301-1526.29.2.103

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Background: Isoprostanes and in particular 8-epi-PGF(2 alpha) have been claimed as a useful measure for in-vivo oxidation injury. While smokers show elevated 8-epi-PGF(2 alpha) the behaviour during quitting smoking is unknown. Methods and results: We determined 8-epi-PGF(2 alpha) in 7 healthy adults ready to quit smoking in plasma, serum and urine by means of an enzyme immunoassay, after extraction and purification before quitting smoking and during a follow-up period of 4 weeks. After quitting smoking, 8-epi-PGF(2 alpha) shows a rapid decline within a few days almost completely normalizing with in 4 weeks. Conclusion: The cigarette-smoking associated in-vivo oxidation injury almost completely disappears within 4 weeks of quitting smoking.

引用

页码：103 / 105

页数：3

共 21 条

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Aghajanian AA, 1997, VASA-J VASCULAR DIS, V26, P65

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