Piroxicam and tenoxicam selective membrane sensors

The construction and general performance characteristics of potentiometric plastic-membrane sensors for piroxicam and tenoxicam drug-anions are described. The electroactive materials are based on ion pair complexes with aliquot 336S cation. Both electrodes show near Nernstian response over the range 10(-2)-10(-5) mol/l, with a detection limit of about 2.4 x 10(-6) mol/l for piroxicam and 6 x 10(-6) mol/l for tenoxicam. The selectivity of the electrodes to a number of organic and non-organic anions is reported. The electrodes proved useful in the determination of the active ingredient in their respective pharmaceutical preparations. The method is simple, rapid and does not require prior sample pre-treatment. (C) 2000 Elsevier Science B.V. All rights reserved.