Replication fork stalling at natural impediments

被引：401

作者：

Mirkin, Ekaterina V. ^{[1
]}

Mirkin, Sergei M. ^{[1
]}

机构：

[1] Univ Illinois, Coll Med, Dept Biochem & Mol Genet, Chicago, IL 60607 USA

来源：

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | 2007年 / 71卷 / 01期

关键词：

D O I：

10.1128/MMBR.00030-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Accurate and complete replication of the genome in every cell division is a prerequisite of genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely precise and robust molecular machines that have evolved to be up to the task. However, it has recently become clear that the replication fork is more of a hurdler than a runner: it must overcome various obstacles present on its way. Such obstacles can be called natural impediments to DNA replication, as opposed to external and genetic factors. Natural impediments to DNA replication are particular DNA binding proteins, unusual secondary structures in DNA, and transcription complexes that occasionally (in eukaryotes) or constantly (in prokaryotes) operate on replicating templates. This review describes the mechanisms and consequences of replication stalling at various natural impediments, with an emphasis on the role of replication stalling in genomic instability. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

引用

页码：13 / 35

页数：23

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