Molecular cytogenetic parameters in Ewing sarcoma

被引：19

作者：

Amiel, A ^{[1
]}

Ohali, A

Fejgin, A

Sardos-Albertini, F

Bouaron, N

Cohen, IJ

Yaniv, I

Zaizov, R

Avigad, S

机构：

[1] Sapir Med Ctr, Inst Genet, IL-44281 Kefar Sava, Israel

[2] Bar Ilan Univ, Felsenstein Med Res Ctr, Petah Tiqwa, Israel

[3] Tel Aviv Univ, IL-69978 Tel Aviv, Israel

[4] Schneider Childrens Med Ctr Israel, Petah Tiqwa, Israel

来源：

CANCER GENETICS AND CYTOGENETICS | 2003年 / 140卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(02)00659-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To evaluate possible genomic instability and possible random aneuploidy, we applied comparative genomic hybridization and fluorescence in situ techniques, and evaluated telomerase activity in 16 cases of Ewing sarcoma (EWS) and compared the results to 7 controls. Common secondary aberrations (gains of chromosomes 8 and 12) were found in the study group. There was a direct correlation between the detection of random aneuploidy and development of tumor relapse (P = 0.0047). Other detectable abnormal parameters (secondary) and high telomerase activity were also more common among the cases with relapse but did not reach a statistical significance (probably because of the small sample size). In EWS, the detection of random aneuploidy seems to be a sensitive parameter in the prediction of tumor relapse. (C) 2003 Elsevier Science Inc. All rights reserved.

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收藏

页码：107 / 112

页数：6

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