Anxiolytic and antiemetic activity of Zingiber officinale

被引：49

作者：

Vishwakarma, SL ^{[1
]}

Pal, SC ^{[1
]}

Kasture, VS ^{[1
]}

Kasture, SB ^{[1
]}

机构：

[1] NDMVP, Samajs Coll Pharm, Nasik 422002, India

来源：

PHYTOTHERAPY RESEARCH | 2002年 / 16卷 / 07期

关键词：

Zingiber officinale; antiemetic; anticonvulsant; anxiolytic;

D O I：

10.1002/ptr.948

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The benzene fraction (1317) of a petroleum ether extract of dried rhizomes of ginger, which contained anticonvulsant principle(s), was screened for anxiolytic and antiemetic activity. Motor coordination was not affected by BIT per se, but diazepam-induced motor incoordination was potentiated. Animals treated with BF showed decreased occupancy in the closed arm of the elevated plus maze suggesting the presence of anxiolytic principles in the BF. BF also blocked lithium sulphate-induced conditioned place aversion indicating antiemetic activity. These findings suggest that the fraction (BF) possesses anticonvulsant, anxiolytic and antiemetic activity. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

收藏

页码：621 / 626

页数：6

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