AMEBA: An acid sensitive aldehyde resin for solid phase synthesis

被引：89

作者：

Fivush, AM ^{[1
]}

Willson, TM ^{[1
]}

机构：

[1] GLAXO INC,RES & DEV,DEPT MED CHEM,RES TRIANGLE PK,NC 27709

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(97)01771-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidation of 4-(3-methoxy-4-hydroxymethylphenoxy)methyl polystyrene resin produced AMEBA resin 1, a novel acid sensitive aldehyde resin. Reductive amination of AMEBA resin generated resin bound amines which were derivatized as sulfonamides, amides, ureas, and carbamates. Cleavage of the resin under mild acidic conditions generated the derivatized amines in high purity and moderate yield. (C) 1997 Elsevier Science Ltd.

引用

页码：7151 / 7154

页数：4

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