Arylimino-1,2,4-thiadiazolidinones: A new family of potassium channel openers

被引：16

作者：

Martinez, A ^{[1
]}

Castro, A ^{[1
]}

Cardelus, I ^{[1
]}

Llenas, J ^{[1
]}

Palacios, JM ^{[1
]}

机构：

[1] LABS ALMIRALL SA, BARCELONA 08024, SPAIN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1997年 / 5卷 / 07期

关键词：

D O I：

10.1016/S0968-0896(97)00077-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of arylimino-1,2,4-thiadiazolidines were prepared using an efficient synthesis starting from thiadiazolopyridinium chlorides. All the compounds showed smooth muscular relaxant properties in rat portal veins. The different behaviour under highly depolarized conditions and the reduction of the biological effect by glyburide suggests that the arylimino-1,2,4-thiadiazolidin-3-ones may act, at least in part, via K+-induced hyperpolarization of vascular smooth cells. (C) 1997 Elsevier Science Ltd.

引用

页码：1275 / 1283

页数：9

共 27 条

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