Cell senescence and cancer

被引：205

作者：

Mathon, NE

Lloyd, AC

机构：

[1] UCL, MRC, Mol Cell Biol Lab, London WC1E 6BT, England

[2] UCL, Dept Biochem, London WC1E 6BT, England

来源：

NATURE REVIEWS CANCER | 2001年 / 1卷 / 03期

关键词：

D O I：

10.1038/35106045

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Historically, the senescent state has been associated with, and was named after, the cell-cycle arrest that occurs after cells have undergone an intrinsically defined number of divisions in vitro. More recently, however, it has been shown that extrinsic factors, including those encountered in normal tissue-culture environments, can prematurely induce an indistinguishable senescent phenotype. In this review, we discuss the pathways of cell senescence, the mechanisms involved and the role that these pathways have in regulating the initiation and progression of cancer.

引用

收藏

页码：203 / 213

页数：11

相关论文

共 112 条

[1] TRANSGENIC MODELS OF TUMOR-DEVELOPMENT [J].

ADAMS, JM ;

CORY, S .

SCIENCE, 1991, 254 (5035) :1161-1167

[2] TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS [J].

ALLSOPP, RC ;

VAZIRI, H ;

PATTERSON, C ;

GOLDSTEIN, S ;

YOUNGLAI, EV ;

FUTCHER, AB ;

GREIDER, CW ;

HARLEY, CB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10114-10118

[3] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].

AMES, BN ;

SHIGENAGA, MK ;

HAGEN, TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922

[4] Mice without telomerase: what can they teach us about human cancer? [J].

Artandi, SE ;

DePinho, RA .

NATURE MEDICINE, 2000, 6 (08) :852-855

[5] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].

Artandi, SE ;

Chang, S ;

Lee, SL ;

Alson, S ;

Gottlieb, GJ ;

Chin, L ;

DePinho, RA .

NATURE, 2000, 406 (6796) :641-645

[6] A critical role for telomeres in suppressing and facilitating carcinogenesis [J].

Artandi, SE ;

DePinho, RA .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (01) :39-46

[7] Telomere states and cell fates [J].

Blackburn, EH .

NATURE, 2000, 408 (6808) :53-56

[8] FUNCTIONAL-CHARACTERIZATION AND DEVELOPMENTAL REGULATION OF MOUSE TELOMERASE RNA [J].

BLASCO, MA ;

FUNK, W ;

VILLEPONTEAU, B ;

GREIDER, CW .

SCIENCE, 1995, 269 (5228) :1267-1270

[9] Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis [J].

Blasco, MA ;

Rizen, M ;

Greider, CW ;

Hanahan, D .

NATURE GENETICS, 1996, 12 (02) :200-204

[10] Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [J].

Blasco, MA ;

Lee, HW ;

Hande, MP ;

Samper, E ;

Lansdorp, PM ;

DePinho, RA ;

Greider, CW .

CELL, 1997, 91 (01) :25-34

← 1 2 3 4 5 6 7 8 9 10 →